Starr John M, Deary Ian J, Fox Helen C, Whalley Lawrence J
Department of Geriatric Medicine, University of Edinburgh, Scotland, UK.
Addict Behav. 2007 Jan;32(1):63-8. doi: 10.1016/j.addbeh.2006.03.020. Epub 2006 May 2.
Previously we reported that smoking is associated with a small relative decline in cognition from childhood to old age. In this study we perform confirmatory analyses on a further wave of data collected from 298 of the participants, all with age 11 IQ scores, at age 66years, 2years after the original observations. Non-smokers scored a mean 4.9 memory test and 2.6 information processing speed test points and ex-smokers 3.5 memory test and 1.9 information processing speed test points higher than current smokers respectively over the two waves of testing, equivalent to 4-8% of mean test scores, adjusted for the effects of childhood IQ. Across tests a 100l/min higher Peak Expiratory Flow Rate was associated with a 3-4% higher test score at ages 64 and 66years. These data confirm the adverse effect of smoking on information processing speed, and provide new evidence for a similar adverse effect on memory for people in their mid-sixties.
此前我们报道过，从童年到老年，吸烟与认知能力的小幅相对下降有关。在本研究中，我们对从298名参与者中收集的另一波数据进行了验证性分析，所有参与者在11岁时都有智商得分，在66岁时，即原始观察后的2年。在两轮测试中，非吸烟者的记忆测试平均得分比当前吸烟者高4.9分，信息处理速度测试得分高2.6分，戒烟者的记忆测试得分比当前吸烟者高3.5分，信息处理速度测试得分高1.9分，相当于平均测试得分的4-8%，并对童年智商的影响进行了调整。在64岁和66岁时，呼气峰值流速每增加100升/分钟，测试得分就会提高3-4%。这些数据证实了吸烟对信息处理速度的不利影响，并为60多岁的人在记忆方面的类似不利影响提供了新证据。
