环境微生物学的基因组学

Genomics for environmental microbiology.

作者信息

Deutschbauer Adam M, Chivian Dylan, Arkin Adam P

机构信息

Lawrence Berkeley National Laboratory, CA 94720, USA.

出版信息

Curr Opin Biotechnol. 2006 Jun;17(3):229-35. doi: 10.1016/j.copbio.2006.04.003. Epub 2006 May 2.

DOI:10.1016/j.copbio.2006.04.003

PMID:16650754

Abstract

The utilization of natural microbial diversity in biotechnology is hindered by our inability to culture the vast majority of microorganisms and the observation that laboratory engineered bacteria rarely function in the wild. It is now clear that an understanding of the community structure, function and evolution of bacteria in their natural environments is required to meet the promise of microbial biotechnology. To meet these new challenges, microbiologists are applying the tools of genomics and related high-throughput technologies to both cultured microbes and environmental samples. This work will lead to new views on ecosystems and biological function together with the biotechnology enabled by this science.

摘要

我们无法培养绝大多数微生物，且实验室改造的细菌在自然环境中很少能发挥作用，这阻碍了生物技术对天然微生物多样性的利用。现在很清楚的是，要实现微生物生物技术的前景，就需要了解细菌在其自然环境中的群落结构、功能和进化。为应对这些新挑战，微生物学家正在将基因组学工具及相关高通量技术应用于培养的微生物和环境样本。这项工作将带来关于生态系统和生物功能的新观点，以及这项科学所推动的生物技术。