猫血浆组胺浓度及外周血嗜酸性粒细胞中的组胺检测
Plasma histamine concentration and histamine detection in peripheral blood eosinophils in cats.
作者信息
Kadoya Michiyo, Momoi Yasuyuki, Iwasaki Toshiroh
机构信息
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
出版信息
J Feline Med Surg. 2006 Oct;8(5):302-8. doi: 10.1016/j.jfms.2006.02.006. Epub 2006 May 2.
Abstract
Plasma histamine levels were measured in 11 clinically healthy cats and 15 cats with allergic dermatitis. Histamine levels were markedly elevated in 5/15 allergic cats. A calcium ionophore, A23187, stimulates histamine release from feline peripheral blood cells. Immunostaining of blood smears from clinically healthy cats revealed that approximately 10% of eosinophils possessed histamine-containing granules. These results indicate that some peripheral eosinophils in cats contain histamine and can release histamine by appropriate stimulation.
摘要
在11只临床健康的猫和15只患有过敏性皮炎的猫中测量了血浆组胺水平。15只过敏性猫中有5只组胺水平显著升高。钙离子载体A23187可刺激猫外周血细胞释放组胺。对临床健康猫的血涂片进行免疫染色显示，约10%的嗜酸性粒细胞含有含组胺的颗粒。这些结果表明，猫的一些外周嗜酸性粒细胞含有组胺，并可通过适当刺激释放组胺。
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