Hara Hidehiko, Nakamura Masato, Palmaz Julio C, Schwartz Robert S
Minnesota Cardiovascular Research Institute, Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, 920 East 28th Street Suite 620, Minneapolis, MN, 55407, USA.
Adv Drug Deliv Rev. 2006 Jun 3;58(3):377-86. doi: 10.1016/j.addr.2006.01.022. Epub 2006 Mar 6.
More than 15 years have passed since stent technology was introduced by Sigwart et al. [U. Sigwart, J. Puel, V. Mirkovitch, F. Joffe, et al. Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N. Engl. J. Med. 316 (1987) 701-706.] among interventional cardiologists. Recently drug eluting stents have assumed dominance in the interventional world as positive trial results revealed their efficacy for preventing restenosis. Stent design, delivery-vehicle materials, and drug properties affect the function of these stents. Stainless steel stents with tubular and multicellular design have proven superior to coil or hybrid stent models. This chapter describes stents which have subtle influences of modular design, metal coverage, strut thickness, strut shape, surface smoothness, and coating materials like an alloy composition.
自西格瓦特等人[U. 西格瓦特、J. 皮尔、V. 米尔科维奇、F. 乔菲等人。血管内支架预防经皮腔内血管成形术后的闭塞和再狭窄。《新英格兰医学杂志》316 (1987) 701 - 706。]将支架技术引入介入心脏病学家领域以来，已经过去了15年多。最近，药物洗脱支架在介入领域占据了主导地位，因为阳性试验结果显示了它们在预防再狭窄方面的疗效。支架设计、输送载体材料和药物特性会影响这些支架的功能。事实证明，具有管状和多细胞设计的不锈钢支架优于线圈或混合支架模型。本章描述了在模块化设计、金属覆盖率、支柱厚度、支柱形状、表面光滑度以及涂层材料（如合金成分）等方面具有细微影响的支架。
