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Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.

作者信息

Rockway Todd W, Zhang Rong, Liu Dachun, Betebenner David A, McDaniel Keith F, Pratt John K, Beno David, Montgomery Debra, Jiang Wen W, Masse Sherie, Kati Warren M, Middleton Tim, Molla Akhteruzzaman, Maring Clarence J, Kempf Dale J

机构信息

Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL 60064-6217, USA.

出版信息

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3833-8. doi: 10.1016/j.bmcl.2006.04.022. Epub 2006 May 2.

DOI:10.1016/j.bmcl.2006.04.022
PMID:16650984
Abstract

A series of non-nucleoside HCV NS5B polymerase inhibitors based on the N-1-benzyl or N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine core substituted in the D-ring aromatic moiety have been prepared and evaluated. Aromatic substituents extending from position 7 of the D-ring exhibited excellent potency against both genotypes 1a and 1b.

摘要

相似文献

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