Reeves Gabrielle A, Thornton Janet M
EMBL--European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R81-7. doi: 10.1093/hmg/ddl086.
Owing to the ongoing success of the genome sequencing and structural genomics projects, the increase in both sequence and structural data is rapid. The development of tools for the annotation of sequence and structural data has become more important in the hope of keeping up with this data explosion. Scientists in this field have addressed these issues over the last 10 years and there now exists a wealth of methods and approaches to help interpret these data. However, there is no current way in which these methods can be incorporated easily so that the resulting annotations can be viewed together. This review discusses the development of these annotation methods and introduces the BioSapiens Network of Excellence, which has been formed in order to integrate the methods which have been developed in Europe.
由于基因组测序和结构基因组学项目不断取得成功，序列和结构数据的增长十分迅速。为了跟上这种数据爆炸式增长的步伐，用于注释序列和结构数据的工具开发变得愈发重要。在过去十年中，该领域的科学家们一直在解决这些问题，现在已有大量方法和途径来帮助解读这些数据。然而，目前尚无简便方法能够整合这些方法，以便将生成的注释放在一起查看。本综述讨论了这些注释方法的发展，并介绍了卓越生物智人网络，该网络的组建目的是整合欧洲已开发的各种方法。
