前列腺腺癌中的肌成纤维细胞性基质反应以及肌腱蛋白-C和层粘连蛋白的表达

Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma.

作者信息

Tomas D, Ulamec M, Hudolin T, Bulimbasić S, Belicza M, Kruslin B

机构信息

Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia.

出版信息

Prostate Cancer Prostatic Dis. 2006;9(4):414-9. doi: 10.1038/sj.pcan.4500874. Epub 2006 May 2.

DOI:10.1038/sj.pcan.4500874

PMID:16652121

Abstract

The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoral tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.

摘要

本研究的目的是分析前列腺癌中基质变化与肌腱蛋白-C（TN-C）和层粘连蛋白表达之间的关系。与肿瘤周围组织和良性前列腺增生相比，癌组织中肌腱蛋白-C免疫染色增加，而层粘连蛋白减少（P<0.05）。统计分析证实前列腺癌中基质变化与TN-C表达之间存在关联（P<0.05）。与Gleason 4级癌相比，Gleason 3级癌显示出更明显的基质反应和TN-C表达（P<0.05）。前列腺癌基质中的主要细胞是肌成纤维细胞，它们也负责肌腱蛋白的产生。层粘连蛋白的降解与肌成纤维细胞性基质变化无关。