在妊娠11 + 0至13 + 6周时通过三维超声测量双胎和三胎妊娠的胎盘体积。

Placental volume in twin and triplet pregnancies measured by three-dimensional ultrasound at 11 + 0 to 13 + 6 weeks of gestation.

作者信息

Wegrzyn P, Fabio C, Peralta A, Faro C, Borenstein M, Nicolaides K H

机构信息

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.

出版信息

Ultrasound Obstet Gynecol. 2006 Jun;27(6):647-51. doi: 10.1002/uog.2783.

DOI:10.1002/uog.2783

PMID:16652407

Abstract

OBJECTIVE

To compare the placental volume at 11 + 0 to 13 + 6 weeks' gestation between singleton and multiple pregnancies and to examine the possible effect of chorionicity on placental volume.

METHODS

The placental volume was measured by three-dimensional (3D) ultrasound using the Virtual Organ Computer-aided AnaLysis (VOCAL) technique in 290 consecutive twin and 37 triplet pregnancies at 11 + 0 to 13 + 6 weeks of gestation. For the comparison of twin, triplet and singleton placental volumes each measurement was expressed as a multiple of the median (MoM) for singletons, previously established from the study of 417 normal fetuses at 11 + 0 to 13 + 6 weeks of gestation.

RESULTS

Median twin and triplet placental volumes were 1.66 and 2.28 MoM for singletons, respectively. In twins the placental volumes increased significantly with gestation from a median of 83.6 mL (5th and 95th centiles: 56.0 mL and 124.9 mL) at 11 + 0 weeks to 149.3 mL (5th and 95th centiles: 100.0 mL and 223.1 mL) at 13 + 6 weeks. The median MoM in monochorionic twins was not significantly different from that in dichorionic twins with fused placentas or dichorionic twins with separate placentas. In triplets the placental volumes increased significantly with gestation from a median of 114.9 mL (5th and 95th centiles: 77.6 mL and 170.1 mL) at 11 weeks to 217.9 mL (5th and 95th centiles: 147.2 mL and 322.5 mL) at 13 + 6 weeks. There were no significant differences in total placental volume between monochorionic and dichorionic triplets, monochorionic and trichorionic triplets, or dichorionic and trichorionic triplets.

CONCLUSIONS

Placental volume in multiple pregnancies does not depend on chorionicity, and the rate of placental growth between 11 and 13 + 6 weeks is not significantly different between singletons, twins and triplets. Moreover, for a given gestational age the placental volume corresponding to each fetus in twins and triplets is 83% and 76%, respectively, of the placental volume in singletons.

摘要

目的

比较单胎妊娠与多胎妊娠在孕11 + 0至13 + 6周时的胎盘体积，并研究绒毛膜性对胎盘体积的可能影响。

方法

采用虚拟器官计算机辅助分析（VOCAL）技术，通过三维（3D）超声对290例连续的双胎妊娠和37例三胎妊娠在孕11 + 0至13 + 6周时的胎盘体积进行测量。为比较双胎、三胎和单胎的胎盘体积，每次测量结果均表示为单胎中位数倍数（MoM），单胎中位数倍数是先前对417例孕11 + 0至13 + 6周的正常胎儿进行研究得出的。

结果

双胎和三胎胎盘体积的中位数分别为单胎的1.66倍和2.28倍。在双胎妊娠中，胎盘体积随孕周显著增加，从孕11 + 0周时的中位数83.6 mL（第5和第95百分位数：56.0 mL和124.9 mL）增加到孕13 + 6周时的149.3 mL（第5和第95百分位数：100.0 mL和223.1 mL）。单绒毛膜双胎的中位数MoM与融合胎盘的双绒毛膜双胎或胎盘分离的双绒毛膜双胎相比，差异无统计学意义。在三胎妊娠中，胎盘体积随孕周显著增加，从孕11周时的中位数114.9 mL（第5和第95百分位数：77.6 mL和170.1 mL）增加到孕13 + 6周时的217.9 mL（第5和第95百分位数：147.2 mL和322.5 mL）。单绒毛膜三胎与双绒毛膜三胎、单绒毛膜三胎与三绒毛膜三胎、双绒毛膜三胎与三绒毛膜三胎之间的胎盘总体积差异均无统计学意义。