多形核白细胞对水痘-带状疱疹病毒抗原的趋化作用。

Chemotaxis of polymorphonuclear leukocytes to varicella-zoster virus antigens.

作者信息

Ihara T, Yasuda N, Kamiya H, Torigoe S, Sakurai M

机构信息

Department of Pediatrics, Mie National Hospital, Japan.

出版信息

Microb Pathog. 1991 Jun;10(6):451-8. doi: 10.1016/0882-4010(91)90110-v.

DOI:10.1016/0882-4010(91)90110-v

PMID:1665536

Abstract

Chemotaxis of polymorphonuclear leukocytes (PMNs) to various varicella-zoster virus (VZV) antigens was studied using a membrane filter method. Chemotactic activity of PMNs was detected in the presence of sonicated VZV antigen and soluble VZV skin test antigen. This activity was reduced when sonicated VZV antigen was treated with human seropositive serum or murine monoclonal antibodies which reacted with glycoprotein (GP) I or GP II of VZV. However, chemotaxis of PMNs was not reduced when sonicated VZV antigen was treated with human seronegative serum or a murine monoclonal antibody which reacted with GP IV. These results suggest that GP I and GP II act as chemoattractants to PMNs, and this mechanism might contribute to the resolution of the skin lesions of varicella and herpes zoster.

摘要

采用膜滤法研究了多形核白细胞（PMNs）对各种水痘-带状疱疹病毒（VZV）抗原的趋化作用。在存在经超声处理的VZV抗原和可溶性VZV皮肤试验抗原的情况下，检测到了PMNs的趋化活性。当经超声处理的VZV抗原用人血清阳性血清或与VZV糖蛋白（GP）I或GP II反应的鼠单克隆抗体处理时，这种活性降低。然而，当经超声处理的VZV抗原用人血清阴性血清或与GP IV反应的鼠单克隆抗体处理时，PMNs的趋化作用并未降低。这些结果表明，GP I和GP II作为PMNs的趋化因子，这种机制可能有助于水痘和带状疱疹皮肤损伤的消退。