Fujiwara T, Ihara T, Yamawaki K, Ito M, Kamiya H, Sakurai M
Department of Pediatrics, Mie University, Japan.
Acta Paediatr Jpn. 1994 Aug;36(4):341-6. doi: 10.1111/j.1442-200x.1994.tb03198.x.
Hydrogen peroxide (H2O2) generation by human polymorphonuclear leukocytes (PMN) incubated with varicella zoster virus (VZV) antigen was studied by cytofluorography. Hydrogen peroxide generation was detected in the presence of VZV-seropositive sera. When seropositive sera were heat-inactivated, H2O2 generation was reduced. When PMN were pre-incubated with Leu-11b, a monoclonal antibody to the Fc receptor on PMN, H2O2 generation was also reduced. These results suggest that VZV antigen-antibody-complement complexes induce H2O2 generation by PMN after these complexes attach to Fc receptors on PMN.
采用细胞荧光成像法研究了人多形核白细胞（PMN）与水痘带状疱疹病毒（VZV）抗原一起孵育时过氧化氢（H2O2）的生成情况。在VZV血清反应阳性的血清存在下可检测到过氧化氢的生成。当血清反应阳性的血清经热灭活后，H2O2的生成减少。当PMN与Leu-11b（一种针对PMN上Fc受体的单克隆抗体）预孵育时，H2O2的生成也减少。这些结果表明，VZV抗原-抗体-补体复合物在附着于PMN上的Fc受体后可诱导PMN生成H2O2。
