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[精神分裂症和阿尔茨海默型老年痴呆症患者脑结构蛋白质谱的二维电泳分析]

[Two-dimensional electrophoretic analysis of the protein spectrum of human brain structures in schizophrenia and senile dementia of the Alzheimer type].

作者信息

Smirnov A V, Shevtsov P N, Burbaeva G Sh

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(10):34-6.

PMID:1665648
Abstract

Analysis was made of the composition of four structures of human brain in health (n-12), schizophrenia (n-10), and Alzheimer's senile dementia (n-8). Protein maps obtained by means of two-dimensional electrophoresis were used to analyze tissue samples of the structures under study. In the investigation, the neocortex was represented by the frontal cortex (field 10), the old cortex by the hippocamp, the midbrain by black substance, and medulla oblongata by the inferior olive. Comparative study of the protein maps revealed quantitative differences in certain brain structures in health as well as differences between these structures in health and mental pathology.

摘要

对健康人(n = 12)、精神分裂症患者(n = 10)和阿尔茨海默氏老年性痴呆患者(n = 8)的人脑四种结构的组成进行了分析。通过二维电泳获得的蛋白质图谱用于分析所研究结构的组织样本。在研究中,新皮质由额叶皮质(第10区)代表,旧皮质由海马体代表,中脑由黑质代表,延髓由下橄榄核代表。蛋白质图谱的比较研究揭示了健康状态下某些脑结构的定量差异以及这些结构在健康与精神病理学之间的差异。

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