Burbaeva G Sh, Aksenova M V, Bibikova V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(9):1374-8.
The creatine kinase (CPK) activity and content were determined in certain brain structures of patients with Alzheimer's disease and senile dementia and in the control group. The findings demonstrated the 5-10-fold decrease of CPK activity in the majority of the investigated brain areas and a 30-fold decrease in the occipital gyrus. The activity decrease did not depend on postmortal interval, sex and age. The content of CPK was increased in the same structures (130% of the control level). So an elevation in CPK values appears to compensate for the fall in CPK activity. Such phenomena can lead to different disturbances in energy metabolism of the brain in mental patients.
测定了阿尔茨海默病和老年痴呆症患者以及对照组某些脑结构中的肌酸激酶（CPK）活性和含量。研究结果表明，在大多数被研究的脑区中，CPK活性下降了5至10倍，枕叶中下降了30倍。活性下降与死后间隔时间、性别和年龄无关。CPK的含量在相同结构中有所增加（为对照水平的130%）。因此，CPK值的升高似乎是为了补偿CPK活性的下降。这种现象可能导致精神疾病患者大脑能量代谢的不同紊乱。
