Burbaeva G Sh, Aksenova M V, Makarenko I G, Kalinenko O O
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(10):49-52.
Immunochemical and immunocytochemical studies were carried out to reveal the cerebral isozyme creatine phosphokinase (CPK BB) in autopsy brain of patients with different mental diseases. The studies covered schizophrenic patients (n-19), patients with senile dementia (n-9), with Alzheimer's disease (n-13) and controls without any mental pathology (n-17). It has been demonstrated that in mental pathology in the frontal cortex (field 10), there was an appreciable decrease in the content of immunoreactive CPK BB. That decrease was significantly more pronounced in Alzheimer's disease than in schizophrenia or senile dementia (p less than 0.01). Apparently, the decrease of the content of immunoreactive CPK BB determines to a considerable measure the early detected decrease of CPK BB activity in the patients' brain.
开展了免疫化学和免疫细胞化学研究，以揭示不同精神疾病患者尸检脑内的脑型肌酸磷酸激酶（CPK BB）。研究对象包括精神分裂症患者（n = 19）、老年痴呆症患者（n = 9）、阿尔茨海默病患者（n = 13）以及无任何精神病理学问题的对照组（n = 17）。结果表明，在额叶皮质（第10区）出现精神病理学改变时，免疫反应性CPK BB的含量明显降低。这种降低在阿尔茨海默病中比在精神分裂症或老年痴呆症中更为显著（p < 0.01）。显然，免疫反应性CPK BB含量的降低在很大程度上决定了患者脑内早期检测到的CPK BB活性下降。
