Krishnan S, Nash J F, Maickel R P
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1334.
Alcohol. 1991 Sep-Oct;8(5):401-4. doi: 10.1016/0741-8329(91)90663-h.
The individual and interactive effects of immobilization stress, ACTH11-24 and ACTH4-10 on the free-choice consumption of ethanol in rats were studied. Stress and ethanol both result in activation of the HPA axis and release of ACTH1-39. The animals were offered a two-bottle choice consumption of 0.2% saccharin and 10% ethanol. They were exposed to immobilization stress or IP injections of ACTH4-10 or ACTH11-24 on an irregular, unpredictable schedule. Stress resulted in a decrease in ethanol consumption during the stress period while ACTH11-24 was devoid of any effect. The ACTH4-10 fragment produced an almost complete block of ethanol consumption during the injection period. Saccharin consumption was not affected by any of the above treatments. These results suggest an important role for ACTH4-10 (produced from ACTH1-39) in ethanol consummatory behavior in rats.
研究了制动应激、促肾上腺皮质激素11 - 24（ACTH11 - 24）和促肾上腺皮质激素4 - 10（ACTH4 - 10）对大鼠乙醇自由选择摄入量的个体及交互作用。应激和乙醇都会导致下丘脑 - 垂体 - 肾上腺（HPA）轴激活及促肾上腺皮质激素1 - 39（ACTH1 - 39）释放。给动物提供0.2%糖精和10%乙醇的双瓶选择摄入实验。它们在不规律、不可预测的时间安排下接受制动应激或腹腔注射ACTH4 - 10或ACTH11 - 24。应激导致应激期间乙醇摄入量减少，而ACTH11 - 24没有任何影响。ACTH4 - 10片段在注射期间几乎完全阻断了乙醇摄入。糖精摄入量不受上述任何处理的影响。这些结果表明ACTH4 - 10（由ACTH1 - 39产生）在大鼠乙醇消费行为中起重要作用。
