用丙咪嗪反复治疗可增强可卡因诱导的多巴胺释放和运动刺激。

Repeated treatment with imipramine potentiates cocaine-induced dopamine release and motor stimulation.

作者信息

Rossetti Z L, D'Aquila P S, Hmaidan Y, Gessa G L, Serra G

机构信息

B.B. Brodie Department of Neurosciences, University of Cagliari, Italy.

出版信息

Eur J Pharmacol. 1991 Aug 29;201(2-3):243-5. doi: 10.1016/0014-2999(91)90353-r.

DOI:10.1016/0014-2999(91)90353-r

PMID:1665784

Abstract

The stimulatory effect of cocaine on locomotor activity and on dopamine efflux from the ventral striatum was studied in rats chronically treated with the antidepressant imipramine. Chronic imipramine (20 mg/kg per day for 3 weeks) potentiated by about 2-fold cocaine-stimulated motor activity and extracellular dopamine concentrations. The results indicate that chronic imipramine facilitates mesolimbic dopamine neurotransmission by potentiating the mechanism which is thought to mediate the rewarding effects of cocaine.

摘要

在长期接受抗抑郁药丙咪嗪治疗的大鼠中，研究了可卡因对运动活性以及腹侧纹状体多巴胺流出的刺激作用。长期给予丙咪嗪（每天20毫克/千克，持续3周）可使可卡因刺激的运动活性和细胞外多巴胺浓度增强约2倍。结果表明，长期使用丙咪嗪通过增强被认为介导可卡因奖赏效应的机制来促进中脑边缘多巴胺神经传递。