Rossetti Z L, Lai M, Hmaidan Y, Gessa G L
B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Eur J Pharmacol. 1993 Oct 5;242(3):313-5. doi: 10.1016/0014-2999(93)90257-i.
Exposure of rate to the behavioral despair test (an animal model of depression) for 40 min resulted in a long-lasting depletion of mesolimbic dopamine output to about 40% of baseline values. The decrease in extracellular dopamine was partially prevented by chronic pretreatment with imipramine (20 mg/kg per day i.p. for 21 days). The results suggest that a fall in mesolimbic dopamine output may be associated with depressive states and indicate that changes in the functional status of the dopamine system contribute to the mechanism of action of imipramine.
将大鼠暴露于行为绝望试验（一种抑郁症动物模型）40分钟，导致中脑边缘多巴胺输出长期耗竭，降至基线值的约40%。慢性给予丙咪嗪预处理（每天腹腔注射20mg/kg，共21天）可部分防止细胞外多巴胺的减少。结果表明，中脑边缘多巴胺输出的下降可能与抑郁状态有关，并表明多巴胺系统功能状态的变化有助于丙咪嗪的作用机制。
