Mezin P, Brion J P, Vermont J, Micoud M, Stoebner P
Cell Pathology Laboratory, A. Michallon Hospital, Grenoble, France.
Ultrastruct Pathol. 1991 Nov-Dec;15(6):593-602. doi: 10.3109/01913129109023189.
Light and electron microscopic studies were performed on neuromuscular biopsy specimens from 12 neurologically affected seropositive patients, 7 with the acquired immune deficiency syndrome (AIDS), 2 with AIDS-related complex, and 3 with no symptoms except for neuropathy. All patients had an axonal injury associated or unassociated with demyelination and peripheral neurogenic atrophy. Capillary lesions were consistently present, which seems to be a new finding. Moreover, tubuloreticular inclusions (TRIs) were found in endomysial (9 of 12 cases) and endoneurial (7 of 12 cases) vessels. Statistical analysis showed that TRIs in more than 20% of endomysial vessels correlated with a survival time shorter than 12 months (P = 0.028). Thus the quantification of TRIs seems to be one of the vital prognostic elements in this patient population.
对12例神经受累的血清学阳性患者的神经肌肉活检标本进行了光镜和电镜研究，其中7例患有获得性免疫缺陷综合征（AIDS），2例患有AIDS相关综合征，3例除神经病变外无其他症状。所有患者均存在与脱髓鞘相关或不相关的轴索损伤以及周围神经源性萎缩。毛细血管病变始终存在，这似乎是一个新发现。此外，在肌内膜血管（12例中的9例）和神经内膜血管（12例中的7例）中发现了管网状包涵体（TRIs）。统计分析表明，超过20%的肌内膜血管中存在TRIs与生存时间短于12个月相关（P = 0.028）。因此，TRIs的定量似乎是该患者群体重要的预后因素之一。
