Bailey R O, Baltch A L, Venkatesh R, Singh J K, Bishop M B
Neurology Services, Veterans Administration Medical Center, Albany, NY.
Neurology. 1988 Jun;38(6):886-91. doi: 10.1212/wnl.38.6.886.
Clinical, laboratory, and pathologic observations in six patients with sensory motor peripheral neuropathy associated with the acquired immunodeficiency syndrome (AIDS) are presented. Blood and urine testing failed to reveal other causes for peripheral neuropathy. Distinctive CSF findings included elevated human immunodeficiency virus-specific indices. Peripheral nerve pathology confirmed the results of electrodiagnostic studies and revealed axonal loss and demyelination. Epineurial and endoneurial mononuclear infiltrates were present in three patients, and in one with early neuropathy, retroviral-like particles were present in peripheral nerve axoplasm. The findings indicate that in some patients with AIDS, neuropathy may be the direct result of a viral insult, although the causes are likely multifactorial.
本文报告了6例与获得性免疫缺陷综合征（AIDS）相关的感觉运动性周围神经病患者的临床、实验室及病理观察结果。血液和尿液检查未发现周围神经病的其他病因。脑脊液的特征性表现包括人类免疫缺陷病毒特异性指标升高。周围神经病理学证实了电诊断研究的结果，显示有轴突丧失和脱髓鞘。3例患者存在神经外膜和神经内膜单核细胞浸润，1例早期神经病患者的周围神经轴浆中存在逆转录病毒样颗粒。这些发现表明，在一些艾滋病患者中，神经病可能是病毒侵袭的直接结果，尽管其病因可能是多因素的。
