Johnston C A, Lopez F, Samson W K, Negro-Vilar A
College of Pharmacy, Washington State University, Pullman 99164-6510.
Neurosci Lett. 1990 Dec 11;120(2):256-8. doi: 10.1016/0304-3940(90)90053-c.
Recently, our laboratory has provided evidence for a physiologically relevant stimulatory influence of oxytocin (OXY) on the preovulatory luteinizing hormone (LH) surge in cycling female rats. The present study evaluated whether this stimulatory effect of OXY on LH release is exerted at a central or peripheral site of action by comparing the ability of peripheral (intravenous) or central (intracerebroventricular) administration of OXY antisera to influence the preovulatory LH surge. The peripheral injection of a very large dose of OXY antisera (0.8 ml) caused a slight attenuation of the early stages of the LH surge. In contrast, the central administration of 5 microliters of OXY antisera completely abolished the preovulatory LH surge. The data support the hypothesis that OXY exerts a physiologically important stimulatory influence on the preovulatory LH surge which is mediated primarily at a central site of action.
最近，我们实验室已提供证据表明，催产素（OXY）对处于发情周期的雌性大鼠排卵前促黄体生成素（LH）峰具有生理相关的刺激作用。本研究通过比较外周（静脉内）或中枢（脑室内）注射OXY抗血清影响排卵前LH峰的能力，评估了OXY对LH释放的这种刺激作用是在中枢还是外周作用部位发挥的。外周注射非常大剂量的OXY抗血清（0.8毫升）会使LH峰早期略有减弱。相比之下，脑室内注射5微升OXY抗血清则完全消除了排卵前LH峰。这些数据支持这样的假说，即OXY对排卵前LH峰发挥生理上重要的刺激作用，这一作用主要是在中枢作用部位介导的。
