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Varicella-zoster virus and subcutaneous cytarabine: correlation of in vitro sensitivities to blood levels.水痘带状疱疹病毒与皮下阿糖胞苷：体外敏感性与血药浓度的相关性
Antimicrob Agents Chemother. 1975 Mar;7(3):229-32. doi: 10.1128/AAC.7.3.229.
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本文引用的文献

1
Determination of plaque inhibitory activity of adenine arabinoside (9-beta-D-arabinofuranosyladenine) for herpesviruses using an adenosine deaminase inhibitor.使用腺苷脱氨酶抑制剂测定阿糖腺苷（9-β-D-阿拉伯呋喃糖基腺嘌呤）对疱疹病毒的噬斑抑制活性。
Antimicrob Agents Chemother. 1974 Jul;6(1):98-101. doi: 10.1128/AAC.6.1.98.
2
Variables influencing the in vitro susceptibilities of herpes simplex viruses to antiviral drugs.影响单纯疱疹病毒体外对抗病毒药物敏感性的变量。
Antimicrob Agents Chemother. 1974 Jul;6(1):34-8. doi: 10.1128/AAC.6.1.34.
3
INHIBITION BY METABOLIC ANALOGUES OF PLAQUE FORMATION BY HERPES ZOSTER AND HERPES SIMPLEX VIRUSES.代谢类似物对带状疱疹病毒和单纯疱疹病毒形成噬斑的抑制作用
J Immunol. 1964 Oct;93:643-8.
4
SPREAD OF ZOSTER VIRUS IN HUMAN EMBRYONIC LUNG CELLS AND THE INHIBITORY EFFECT OF LODODEOXYURIDINE.带状疱疹病毒在人胚肺细胞中的传播及碘脱氧尿苷的抑制作用
Virology. 1964 Mar;22:321-30. doi: 10.1016/0042-6822(64)90023-6.
5
Physical properties of human interferon prepared in vitro and in vivo.体外和体内制备的人干扰素的物理性质。
Virology. 1966 Aug;29(4):515-22. doi: 10.1016/0042-6822(66)90276-5.
6
Cytosine arabinoside therapy for disseminated herpes zoster in a patient with IgG pyroglobulinemia.阿糖胞苷治疗IgG型冷球蛋白血症患者的播散性带状疱疹
Blood. 1969 Nov;34(5):706-11.
7
Improved microbiological assay for cytosine arabinoside (NSC-63878).阿糖胞苷（NSC - 63878）的改良微生物测定法。
Cancer Chemother Rep. 1970 Dec;54(6):393-7.
8
Susceptibility of herpesviruses to cytosine arabinoside: standardization of susceptibility test procedure and relative resistance of herpes simplex type 2 strains.疱疹病毒对阿糖胞苷的敏感性：敏感性试验程序的标准化及2型单纯疱疹病毒株的相对抗性
Antimicrob Agents Chemother. 1972 Apr;1(4):354-7. doi: 10.1128/AAC.1.4.354.
9
Susceptibility of herpesviruses to three nucleoside analogues and their combinations and enhancement of the antiviral effect of acid pH.疱疹病毒对三种核苷类似物及其组合的敏感性以及酸性pH值对抗病毒效果的增强作用。
J Infect Dis. 1974 Jan;129(1):82-5. doi: 10.1093/infdis/129.1.82.
10
Adverse effect of cytosine arabinoside on disseminated zoster in a controlled trial.阿糖胞苷在一项对照试验中对播散性带状疱疹的不良反应。
N Engl J Med. 1973 Oct 25;289(17):873-8. doi: 10.1056/NEJM197310252891701.

水痘带状疱疹病毒与皮下阿糖胞苷：体外敏感性与血药浓度的相关性

Varicella-zoster virus and subcutaneous cytarabine: correlation of in vitro sensitivities to blood levels.

作者信息

Zaky D A, Betts R F, Douglas R G, Bengali K, Neil G L

出版信息

Antimicrob Agents Chemother. 1975 Mar;7(3):229-32. doi: 10.1128/AAC.7.3.229.

DOI:10.1128/AAC.7.3.229
PMID:166610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429116/
Abstract

The susceptibility of 26 strains of varicella-zoster virus to cytarabine was tested in vitro by measuring reduction in number and size of plaques using human foreskin fibroblast cells. Most strains showed 50% reduction of plaque number by 0.125 mug of cytarabine per ml or less. Cytarabine levels in sera of 12 patients after a single subcutaneous injection of 50 mg/M(2) exceeded this inhibitory level for a period of 75 min. Thus, the subcutaneous route is a potentially useful method of administration of cytarabine for antiviral drug trials.

摘要

通过用人包皮成纤维细胞测量空斑数量和大小的减少情况，在体外测试了26株水痘-带状疱疹病毒对阿糖胞苷的敏感性。大多数毒株在每毫升含0.125微克或更低浓度的阿糖胞苷时，空斑数量减少50%。12例患者单次皮下注射50mg/M(2)后血清中的阿糖胞苷水平在75分钟内超过了该抑制水平。因此，皮下途径是阿糖胞苷用于抗病毒药物试验的一种潜在有用的给药方法。