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水痘带状疱疹病毒对阿糖腺苷和阿糖次黄嘌呤的体外敏感性

In vitro susceptibility of varicella zoster virus to adenine arabinoside and hypoxanthine arabinoside.

作者信息

Bryson Y J, Connor J D

出版信息

Antimicrob Agents Chemother. 1976 Mar;9(3):540-3. doi: 10.1128/AAC.9.3.540.

DOI:10.1128/AAC.9.3.540
PMID:176937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429566/
Abstract

The in vitro susceptibility of varicella zoster (VZ) isolates to adenine arabinoside (ara-A) and hypoxanthine arabinoside (ara-Hx) was determined in human skin fibroblasts. Using a system in which deamination was inhibited, and using a modified plaque reduction method, the antiviral activities of ara-A and ara-Hx were separated. The plaque inhibitory concentration of ara-A for all VZ isolates tested was 1 to 2 mug/ml and 80 to 100 mug/ml for ara-Hx. A comparison of antiviral activity based upon total plaque suppression gave a rate of 40 to 50:1, in favor of ara-A.

摘要

在人皮肤成纤维细胞中测定了水痘带状疱疹（VZ）分离株对阿糖腺苷（ara - A）和阿糖次黄嘌呤（ara - Hx）的体外敏感性。使用一种抑制脱氨作用的系统，并采用改良的蚀斑减少法，分离出了ara - A和ara - Hx的抗病毒活性。所测试的所有VZ分离株中，ara - A的蚀斑抑制浓度为1至2微克/毫升，ara - Hx为80至100微克/毫升。基于总蚀斑抑制的抗病毒活性比较得出比率为40至50:1，有利于ara - A。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/429566/d594cae3120e/aac00309-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/429566/d594cae3120e/aac00309-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/429566/d594cae3120e/aac00309-0189-a.jpg

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