母体与新生儿维生素B6代谢之间的关系：酶学研究视角

Relationship between maternal and neonatal vitamin B6 metabolism: perspectives from enzyme studies.

作者信息

Delport R, Ubbink J B, Vermaak W J, Shaw A, Bissbort S, Becker P J

机构信息

Department of Chemical Pathology, University of Pretoria, South Africa.

出版信息

Nutrition. 1991 Jul-Aug;7(4):260-4; discussion 264-6.

PMID:1666321

Abstract

Enzymes involved in vitamin B6 metabolism, i.e., pyridoxal kinase, pyridoxamine (pyridoxine) 5'-phosphate oxidase, and pyridoxal 5'-phosphate phosphatase, were assayed in hemolysates prepared from cord, maternal, and control blood samples. Mean cord and control pyridoxamine (pyridoxine) 5'-phosphate oxidase activities were significantly higher than maternal activities (p less than 0.001 and p less than 0.05, respectively). A significant correlation (p less than 0.001) was observed between maternal and cord vitamin B6-metabolizing enzymes. Cord pyridoxal 5'-phosphate levels correlated significantly with maternal pyridoxal 5'-phosphate levels (p less than 0.001) and with cord pyridoxal kinase activity (p less than 0.05). Maternal pyridoxal 5'-phosphate levels appear to be the most important factor determining fetal vitamin B6 status.

摘要

对从脐带血、母血和对照血样制备的溶血产物中参与维生素B6代谢的酶，即吡哆醛激酶、吡哆胺（吡哆醇）5'-磷酸氧化酶和吡哆醛5'-磷酸磷酸酶进行了检测。脐带血和对照血样中吡哆胺（吡哆醇）5'-磷酸氧化酶的平均活性显著高于母血中的活性（分别为p<0.001和p<0.05）。观察到母血和脐带血中维生素B6代谢酶之间存在显著相关性（p<0.001）。脐带血中吡哆醛5'-磷酸水平与母血中吡哆醛5'-磷酸水平显著相关（p<0.001），与脐带血中吡哆醛激酶活性也显著相关（p<0.05）。母血中吡哆醛5'-磷酸水平似乎是决定胎儿维生素B6状态的最重要因素。