Sergeev P V, Snegireva G V, Gukasov V M, Gatsura V V
Biull Eksp Biol Med. 1991 Oct;112(10):381-2.
Influence of fructose++-1,6-diphosphate, succinate, malate and cytochrome C on free lipid peroxidation (FLP), infarct sizes and metabolic acidosis was studied in experiments on rats. The good correlation between inhibition of FLP and cardioprotector activity was established for activators of glycolytic energy production only. Krebs' cycle metabolites limited the zone of myocardial necrosis after coronary occlusion without any significant depression of FLP. Succinate and malate were practically inactive under acute metabolic acidosis of isolated rat heart.
在大鼠实验中，研究了果糖-1,6-二磷酸、琥珀酸、苹果酸和细胞色素C对游离脂质过氧化（FLP）、梗死面积和代谢性酸中毒的影响。仅对于糖酵解能量产生的激活剂，才确立了FLP抑制与心脏保护活性之间的良好相关性。三羧酸循环代谢产物限制了冠状动脉闭塞后心肌坏死区域，而未显著降低FLP。在离体大鼠心脏急性代谢性酸中毒情况下，琥珀酸和苹果酸实际上无活性。
