[全身麻醉药使磷脂双分子层流化是全身麻醉的一个原因吗？]
[Is fluidization of the phospholipid bilayer by general anesthetics a reason for general anesthesia?].
作者信息
Burt A Iu, Abramov Iu B, Sachkov V I
出版信息
Biull Eksp Biol Med. 1991 Oct;112(10):387-9.
PMID:1666520
Abstract
It was found that chlorpromazine and pipolfene potentiating general anaesthesia increase viscosity of phospholipid membrane in the region of polar headgroups and in the hydrophobic area near glycerol sceleton. These results (independently of potentiating mechanism) confuse a mechanism of anaesthetics action as increased fluidity of membrane phospholipids.
摘要
研究发现，增强全身麻醉作用的氯丙嗪和哌泊非那嗪会增加磷脂膜极性头部区域以及甘油骨架附近疏水区域的粘度。这些结果（与增强机制无关）使麻醉剂作用机制（即膜磷脂流动性增加）变得复杂。
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