全身麻醉的分子机制：II. 突触膜的自旋标记研究。
Molecular mechanism of general anesthesia: II. Spin label studies on synaptic membranes.
作者信息
Mazzanti L, Curatola G, Zolese G, Bertoli E, Lenaz G
出版信息
Boll Soc Ital Biol Sper. 1979 Mar 30;55(6):506-10.
PMID:233072
Abstract
In this communication we report the effects of general anesthetics on the mobility and order of spin labeled stearic acid derivatives in synaptic membranes and in bilayers formed from the lipids extracted therefrom. The anesthetics studied abolish the immobilization induced by synaptic membrane proteins on the membrane lipids : this effect, observed particularly in the bilayer core, is interpreted as a labilization of lipid-protein interactions induced by anesthetics.
摘要
在本通讯中，我们报告了全身麻醉剂对突触膜以及由从中提取的脂质形成的双层膜中自旋标记硬脂酸衍生物的流动性和有序性的影响。所研究的麻醉剂消除了突触膜蛋白对膜脂质诱导的固定作用：这种效应，特别是在双层膜核心中观察到的，被解释为麻醉剂诱导的脂质 - 蛋白质相互作用的不稳定化。
相似文献
1
Molecular mechanism of general anesthesia: II. Spin label studies on synaptic membranes.全身麻醉的分子机制：II. 突触膜的自旋标记研究。
Boll Soc Ital Biol Sper. 1979 Mar 30;55(6):506-10.
2
Molecular mechanism of general anesthesia: I. Fluorescence studies in mitochondrial membranes.全身麻醉的分子机制：I. 线粒体膜的荧光研究。
Boll Soc Ital Biol Sper. 1979 Mar 30;55(6):499-505.
3
4
Spin label studies on the effect of anesthetics in synaptic membranes.关于麻醉剂对突触膜作用的自旋标记研究。
J Neurochem. 1979 Jun;32(6):1689-95. doi: 10.1111/j.1471-4159.1979.tb02280.x.
5
Effect of anesthesia on membrane fluidity and acetylcholinesterase activity in rat brain synaptosomes.麻醉对大鼠脑突触体膜流动性和乙酰胆碱酯酶活性的影响。
Boll Soc Ital Biol Sper. 1980 Jun 15;56(11):1109-13.
6
Effect of anesthetics on membrane fluidity tested by two different techniques: EPR spin labels and polarization of perylene fluorescence.通过两种不同技术（电子顺磁共振自旋标记和苝荧光偏振）测试麻醉剂对膜流动性的影响。
Boll Soc Ital Biol Sper. 1980 Mar 30;56(6):527-32.
7
8
[Is fluidization of the phospholipid bilayer by general anesthetics a reason for general anesthesia?].[全身麻醉药使磷脂双分子层流化是全身麻醉的一个原因吗？]
Biull Eksp Biol Med. 1991 Oct;112(10):387-9.
9
Lipid protein interactions in mitochondria. VIII. Effect of general anesthetics on the mobility of spin labels in lipid vesicles and mitochondrial membranes.线粒体中的脂蛋白相互作用。VIII. 全身麻醉剂对脂质囊泡和线粒体膜中自旋标记物流动性的影响。
J Bioenerg Biomembr. 1979 Apr;11(1-2):17-32. doi: 10.1007/BF00743158.
10
A spin probe study of the effects of chlorpromazine and its derivatives on lipid-protein interactions in synaptosomal membranes.氯丙嗪及其衍生物对突触体膜中脂-蛋白相互作用影响的自旋探针研究。
Gen Physiol Biophys. 1992 Aug;11(4):345-57.
Zotero 插件