Rakhimov K R, Likhovid L V, Shinder D A
Fiziol Zh SSSR Im I M Sechenova. 1991 Oct;77(10):127-33.
Proteolytic activity of the stomach and pancreas as well as glycyl-L-leucin-dipeptide-hydrolase activity of the small intestine after introduction of hydrocortisone on the 1-, 5-, 10-, 16- and 30th days of life was studied in rats. The enzyme system sensitivity responsible for protein hydrolysis was shown to be age-dependent on the hormone administration. The peculiarities of the stomach, pancreas and small intestine responses to the hormone administration was found: the enzyme system inducibility of the pancreas was significantly higher than that of the stomach and the small intestine during the whole suckling period.
研究了氢化可的松分别在大鼠出生后第1、5、10、16和30天注射后,其胃和胰腺的蛋白水解活性以及小肠的甘氨酰-L-亮氨酸二肽水解酶活性。结果表明,负责蛋白质水解的酶系统敏感性在激素给药时具有年龄依赖性。还发现了胃、胰腺和小肠对激素给药反应的特点:在整个哺乳期,胰腺的酶系统诱导性明显高于胃和小肠。