Preobrazhenskiĭ V N, Klimov N P, Bazhanov V L, Ostapenko I L
Ter Arkh. 1991;63(10):71-3.
The authors provide the data on the hormonal spectrum (STH, gastrin, sex hormones) in patients with long unhealing duodenal ulcers. It is shown that changes in the concentrations and ratios of the concentrations of hypophyseal-gonadal hormones may serve as a defensive adaptation reaction of the body and may be due to activation of the adaptation systems that mediate the neurohumoral mechanisms of regulation. Such changes are more remarkable in patients with common peptic ulcer. Apparently, in patients with long unhealing ulcers, these mechanisms tend toward depletion, as a result of which the other mechanisms start prevailing (microcirculatory disorders, immunologic abnormalities, pathological microflora).
作者提供了长期不愈合十二指肠溃疡患者的激素谱（生长激素、胃泌素、性激素）数据。结果表明，垂体-性腺激素浓度及其浓度比值的变化可能是机体的一种防御性适应反应，可能是由于介导神经体液调节机制的适应系统被激活所致。这种变化在普通消化性溃疡患者中更为显著。显然，在长期不愈合溃疡患者中，这些机制趋于耗竭，结果其他机制开始占主导地位（微循环障碍、免疫异常、病理性微生物群）。
