Loginov A S, Arbuzova V G, Amirov N Sh, Astaf'eva O V, Zvenigorodskaia L A
Ter Arkh. 1995;67(10):19-23.
Blood levels of STH, ACTH, somatostatin, bombesin, gastrin, hydrocortisone, aldosterone, testosterone, estradiol, progesterone and gastric juice levels of gastrin and somatostatin were measured in remission and exacerbation of gastric and duodenal ulcer (GU), (DU) using radioimmunoassay. The study included 250 DU, 200 GU and 5O control subjects. As a result, two forms of DU were identified. DU type 1 is characterized by basal and stimulated hypergastrinemia, paradoxical D-cell response to stimulation, high blood concentrations of STH, ACTH, testosterone. Type 2 DU exhibits basal hypogastrinemia, elevated gastrin concentration in response to stimulation, adequate reaction of D-cells, low levels of estradiol and progesterone. In GU there were low concentrations of STH, bombesin, hydrocortisone, estradiol, testosterone, progesterone, somatostatin. D-cell response to loading was adequate. It is concluded that DU and GU pathogeneses are different, that DU is a heterogeneous disease.
采用放射免疫分析法，在胃溃疡（GU）和十二指肠溃疡（DU）的缓解期和发作期，测定了生长激素（STH）、促肾上腺皮质激素（ACTH）、生长抑素、蛙皮素、胃泌素、氢化可的松、醛固酮、睾酮、雌二醇、孕酮的血药浓度以及胃泌素和生长抑素的胃液浓度。该研究纳入了250例十二指肠溃疡患者、200例胃溃疡患者和50例对照受试者。结果，识别出两种类型的十二指肠溃疡。1型十二指肠溃疡的特征为基础和刺激后的高胃泌素血症、D细胞对刺激的反常反应、STH、ACTH、睾酮的高血药浓度。2型十二指肠溃疡表现为基础低胃泌素血症、刺激后胃泌素浓度升高、D细胞反应正常、雌二醇和孕酮水平较低。胃溃疡患者的STH、蛙皮素、氢化可的松、雌二醇、睾酮、孕酮、生长抑素浓度较低。D细胞对负荷的反应正常。得出的结论是，十二指肠溃疡和胃溃疡的发病机制不同，十二指肠溃疡是一种异质性疾病。
