Sutkovoĭ D A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(12):43-6.
Taking into consideration that activation of free radical processes is an indispensable consequence of any extreme action on man and animals and that lipid peroxidation (LPO) metabolites may play a role of original "primary mediators of stress", an attempt was made to define LPO participation in body response to nociceptive stimuli. Investigations carried out in patients belonging to different nosological groups, differing in the intensity of pain, established the presence of a direct relationship between the potency of painful action and LPO activation. LPO activation was also observed in experiments on animals exposed to painful tourniquetting of the limbs. The data obtained allowed a conclusion about possible participation of free radical lipid peroxidation processes in the formation of nociception. This may be confirmed by the circumstance that reflexotherapy determined remarkable LPO activation together with removal of the painful syndrome.
考虑到自由基过程的激活是对人和动物的任何极端作用不可避免的结果，并且脂质过氧化（LPO）代谢产物可能起到原始“应激初级介质”的作用，因此尝试确定LPO在机体对伤害性刺激的反应中的参与情况。对属于不同疾病分类组、疼痛强度不同的患者进行的调查表明，疼痛作用的强度与LPO激活之间存在直接关系。在对肢体进行疼痛性止血带绑扎的动物实验中也观察到了LPO激活。所获得的数据使得可以得出关于自由基脂质过氧化过程可能参与伤害感受形成的结论。反射疗法在消除疼痛综合征的同时确定了显著的LPO激活，这一情况可以证实这一点。
