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[Carnosine prevents the activation of free-radical lipid oxidation during stress].

作者信息

Guliaeva N V, Dupin A M, Levshina I P, Obidin A B, Boldyrev A A

出版信息

Biull Eksp Biol Med. 1989 Feb;107(2):144-7.

PMID:2923966
Abstract

Carnosine (beta-alanyl-L-histidine) injected to intact albino rats (20 mg/kg body weight) induces depletion of lipid peroxidation (LPO) products in brain and blood serum, an increase of superoxide scavenging activity in brain and serum, decrease of cholesterol: phospholipid ratio and increase of easy oxidizable phospholipid portion in brain lipid extracts. After painful stress (footshock during 2 hours) LPO products are accumulated in brain and serum, cholesterol: phospholipid ratio increases and the portion of easy oxidizable phospholipids decreases. Carnosine given before stress prevents LPO activation. Effects of carnosine and stress are not additive: LPO inhibition induced by carnosine is much more in rats subjected to stress.

摘要

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