Guliaeva N V
Nauchnye Doki Vyss Shkoly Biol Nauki. 1989(4):5-14.
The literary data and own results concerning the stages of free radical lipid oxidation inhibition during the adaptation of animals to stress are reviewed. Using the chronic stress models such as immobilization, experimental neurosis, it has been shown, that in general adaptation syndrome the stage of permanent adaptation to stress corresponds to a permanent inhibition of free radical processes in animal tissues. This stage is accompanied by the activation of superoxide radical scavenging and corresponding changes of lipid composition. similar results are obtained on the model of the development of permanent compensation processes after brain injury. Studying the acute stress it has been found, that during first minutes the inhibition of lipid peroxidation which precedes its further activation takes place. This stage corresponds to the realization of urgent adaptation phase to stress. The role of inhibition of free radical processes in mechanisms of urgent and permanent adaptation to stress is under discussion.
综述了有关动物适应应激过程中自由基脂质氧化抑制阶段的文献资料及自身研究结果。利用慢性应激模型，如固定、实验性神经症，研究表明，在一般适应综合征中，对应激的永久适应阶段与动物组织中自由基过程的永久抑制相对应。此阶段伴随着超氧自由基清除的激活以及脂质组成的相应变化。在脑损伤后永久代偿过程发展的模型上也得到了类似结果。研究急性应激时发现，在最初几分钟内会发生脂质过氧化的抑制，随后才进一步激活。该阶段对应于应激紧急适应阶段的实现。自由基过程抑制在应激紧急和永久适应机制中的作用正在讨论之中。
