Δ6 去饱和酶抑制：诺氟沙星的一种新型作用模式。
Delta6 desaturase inhibition : a novel mode of action of norflurazone.
机构信息
The Laboratory for Microalgal Biotechnology, Jacob Blaustein Institute for Desert Research, Ben-Gurion University of the Negev, Sede-Boker Campus 84993, Israel.
出版信息
Plant Physiol. 1990 May;93(1):347-9. doi: 10.1104/pp.93.1.347.
The herbicide Norflurazone was shown to be an inhibitor of fatty acid of the Delta6 desaturation system. Treating cultures of the microalgae Spirulina platensis or Monodus subterraneus with this herbicide brought about a reduction in the level of gamma-linolenic acid and in an increase in the level of linoleic acid. In Monodus, the increase in linoleic acid made it more available for omega3 desaturation, resulting in an increase in the proportion of eicosapentaenoic acid. The proportion of arachidonic acid did not decrease albeit the drastic decrease in its precursor gamma-linolenic acid.
除草剂 Norflurazone 被证明是脂肪酸 Delta6 去饱和系统的抑制剂。用这种除草剂处理微藻螺旋藻或地下 Monodus 的培养物会导致γ-亚麻酸水平降低，亚油酸水平升高。在 Monodus 中，亚油酸水平的升高使其更容易进行 omega3 去饱和，从而导致二十碳五烯酸的比例增加。尽管其前体γ-亚麻酸急剧减少，但花生四烯酸的比例并没有下降。
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