Murata K, Araki S, Yokoyama K
Department of Public Health, Faculty of Medicine, University of Tokyo, Japan.
Am J Ind Med. 1991;20(6):775-84. doi: 10.1002/ajim.4700200609.
To investigate the effects of styrene exposure on peripheral, central, and autonomic nervous system functions in man, we measured the distribution of nerve conduction velocities (DCV), short-latency somatosensory evoked potentials (SSEP), and variability in electrocardiographic R-R interval (CVRR) as well as conventional sensory and motor median nerve conduction velocities (SCV and MCV) in eleven styrene-exposed workers. The styrene workers' urinary phenylglyoxylic acid levels ranged from 31 to 419 (mean 169) mg/g creatinine at the end of the work shift on the examination day (estimated exposure to styrene of 22 ppm in air). Control subjects, matched to each styrene worker by sex and age, were selected from healthy adults without cardiovascular, neurologic and other potentially confounding disorders. In the styrene workers, we found that the V80 velocity of the DCV, below which 80% of active nerve fibers lie, and the SCV were both significantly slowed; the CVRR was also significantly reduced. There were no significant differences in SSEP latencies, MCV, or heart rate between the exposed workers and controls. These data, despite the small sample size, suggest that styrene affects the faster myelinated fibers of the peripheral sensory nerves, and that it also affects autonomic nervous activity.
为研究接触苯乙烯对人体外周、中枢及自主神经系统功能的影响，我们测量了11名接触苯乙烯工人的神经传导速度（DCV）分布、短潜伏期体感诱发电位（SSEP）、心电图R-R间期变异性（CVRR）以及传统的感觉和运动正中神经传导速度（SCV和MCV）。在检查日工作班次结束时，苯乙烯工人尿中苯乙醇酸水平为31至419（平均169）mg/g肌酐（估计空气中苯乙烯暴露量为22 ppm）。对照对象按性别和年龄与每位苯乙烯工人匹配，选自无心血管、神经及其他潜在混杂疾病的健康成年人。在苯乙烯工人中，我们发现DCV中80%活性神经纤维所在速度以下的V80速度以及SCV均显著减慢；CVRR也显著降低。暴露工人与对照之间的SSEP潜伏期、MCV或心率无显著差异。尽管样本量小，但这些数据表明苯乙烯会影响外周感觉神经中髓鞘化较快的纤维，并且还会影响自主神经活动。
