Marchal-Sommé Joëlle, Uzunhan Yurdagul, Marchand-Adam Sylvain, Valeyre Dominique, Soumelis Vassili, Crestani Bruno, Soler Paul
Institut National de la Santé et de la Recherche Médicale Unité 700, Université Paris 7, Faculté de Médecine Xavier Bichat, 75870 Paris Cedex 18, France.
J Immunol. 2006 May 15;176(10):5735-9. doi: 10.4049/jimmunol.176.10.5735.
Ectopic formation of secondary lymphoid tissue is initiated by the local attraction of naive T and B cells. In this study, we describe a novel type of organized lymphoid structure in the lung of human idiopathic pulmonary fibrosis, with key features of lymphoid neogenesis, including: 1) recently activated CD40 ligand (CD40L)+ T cells; 2) variable numbers of activated CD40+/CD40L+ B cells, sometimes organized in follicles; 3) fully mature dendritic cells (DC) expressing CD40, CD83, CD86, and DC-lysosome-associated membrane protein; 4) the expression of the chemokine CCL21; 5) the presence of vessels with characteristics of high endothelial venules; and 6) a dense network of follicular DC. Surprisingly, these structures are devoid of CCR7+ naive T cells, proliferating lymphocytes, and germinal centers, suggesting that newly recruited activated DC and Ag-experienced lymphocytes can drive lymphoid neogenesis and that factors present within the lymphoid aggregates, such as CD40L, are essential to induce DC maturation.
次级淋巴组织的异位形成是由幼稚T细胞和B细胞的局部吸引引发的。在本研究中，我们描述了一种在人类特发性肺纤维化患者肺中出现的新型有组织的淋巴结构，具有淋巴新生的关键特征，包括：1）近期活化的CD40配体（CD40L）+ T细胞；2）数量不等的活化CD40+/CD40L+ B细胞，有时形成滤泡；3）表达CD40、CD83、CD86和DC-溶酶体相关膜蛋白的完全成熟树突状细胞（DC）；4）趋化因子CCL21的表达；5）具有高内皮微静脉特征的血管的存在；6）滤泡DC的密集网络。令人惊讶的是，这些结构缺乏CCR7+幼稚T细胞、增殖淋巴细胞和生发中心，这表明新招募的活化DC和经历过抗原的淋巴细胞可以驱动淋巴新生，并且淋巴聚集物中存在的因子，如CD40L，对于诱导DC成熟至关重要。
