Department of Otolaryngology - Head and Neck Surgery, Georgetown University Hospital, 3800 Reservoir Road, NW 1st Floor Gorman Building, Washington, DC, 20007, USA,
Curr Infect Dis Rep. 2010 Mar;12(2):88-95. doi: 10.1007/s11908-010-0085-4.
Many different treatment options for chronic rhinosinusitis (CRS) exist, but questions remain regarding the best options. Although oral and intravenous antimicrobial therapies have traditionally been prescribed to manage CRS, topical administration of these agents has gained increasing popularity over the past few years. Topical antimicrobial agents are preferable because of their ability to localize delivery to the sinonasal mucosa and minimize the systemic effects seen with oral agents. This quality is especially important in treatment of biofilms, where higher concentrations of antibiotics are usually required. This article gives a brief overview of CRS and provides a summary of recent studies using topical agents for treatment of bacterial and fungal sinusitis.
慢性鼻-鼻窦炎（CRS）有许多不同的治疗选择，但最佳选择仍存在疑问。虽然传统上一直采用口服和静脉内抗菌疗法来治疗 CRS，但近年来局部应用这些药物的方法越来越受欢迎。局部应用抗菌药物是可取的，因为它们能够将药物输送到鼻-鼻窦黏膜并最大限度地减少口服药物引起的全身作用。在治疗生物膜时，这种特性尤为重要，因为通常需要更高浓度的抗生素。本文简要概述了 CRS，并总结了最近使用局部药物治疗细菌性和真菌性鼻窦炎的研究。
