Harish Srinivasan, Lee Justin C, Ahmad Muaaze, Saifuddin Asif
The Department of Radiology, The Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK.
Eur Radiol. 2006 Dec;16(12):2652-60. doi: 10.1007/s00330-006-0267-5. Epub 2006 May 3.
The purpose of this study was to assess the reliability of MR imaging features in distinguishing between benign and malignant soft tissue masses that have a "cyst-like" appearance (hypointense to muscle on T1-weighted and hyperintense on T2-weighted or fluid-sensitive MR sequences). MR imaging features of 40 patients with histologically proven soft tissue masses (27 benign and 13 malignant lesions) that were hypointense to muscle on T1-weighted and hyperintense on T2-weighted or fluid-sensitive MR sequences were analysed to see if a distinction could be made between benign and malignant lesions. There were 23 females and 17 males (mean age, 56 years; age range, 23-82 years). MR imaging features analysed for statistical significance included lesion size, lesion homogeneity, presence of lobulation, depth in relation to fascia and border definition. Clinical assessment included the age and sex of the patient and location of the lesion. Statistically significant MR imaging features favouring a diagnosis of a malignant lesion included larger average dimension of the mass (P < or = 0.004), larger greatest dimension of the mass (P < or = 0.028) and heterogeneity of the lesion on T1-weighted sequences (P = 0.017). The most statistically significant predictor of malignancy was the larger average dimension of the mass.
本研究的目的是评估磁共振成像（MR）特征在鉴别具有“囊肿样”表现（在T1加权像上相对于肌肉呈低信号，在T2加权像或液体敏感MR序列上呈高信号）的良性和恶性软组织肿块方面的可靠性。分析了40例经组织学证实的软组织肿块（27例良性病变和13例恶性病变）患者的MR成像特征，这些肿块在T1加权像上相对于肌肉呈低信号，在T2加权像或液体敏感MR序列上呈高信号，以确定能否区分良性和恶性病变。其中有23名女性和17名男性（平均年龄56岁；年龄范围23 - 82岁）。分析其统计学意义的MR成像特征包括病变大小、病变均匀性、分叶情况、相对于筋膜的深度以及边界清晰度。临床评估包括患者的年龄、性别和病变位置。有利于诊断为恶性病变的具有统计学意义的MR成像特征包括肿块的平均尺寸较大（P≤0.004）、肿块的最大尺寸较大（P≤0.028）以及T1加权序列上病变的异质性（P = 0.017）。恶性肿瘤最具统计学意义的预测指标是肿块的平均尺寸较大。
