外周脱羧酶抑制后二羟基苯丙氨酸和二羟基苯丝氨酸对大鼠睡眠-觉醒周期的作用
The actions of dihydroxyphenylalanine and dihydroxyphenylserine on the sleep-wakefulness cycle of the rat after peripheral decarboxylase inhibition.
作者信息
Altier H, Moldes M, Monti J M
出版信息
Br J Pharmacol. 1975 May;54(1):101-6. doi: 10.1111/j.1476-5381.1975.tb07415.x.
Abstract
- The actions of dihydroxyphenylalanine (DOPA) and dihydroxyphenylserine (DOPS) were assessed on the sleep-wakefulness cycle of male Wistar rats. 2. In comparative studies the extracerebral decarboxylase was inhibited with serinetrihydroxybenzylhydrazide (RO 4-4602) before injection of DOPA or DOPS. 3. DOPA (80-160 mg/kg, i.p.) with or without previous inhibition of the peripheral decarboxylase gave rise to an initial significant increase of slow wave activity, which may be related to a release of 5-hydroxytryptamine. 4. During the subsequent 8 h sessions, DOPA significantly decreased slow wave sleep and rapid eye movement sleep (REM) and increased wakefulness. 5. DOPS (80-160 mg/kg, i.p.) did not significantly modify the sleep-wakefulness cycle apart from a decrease of the latency for the first REM episode after 160 mg/kg in the RO 4-4602 pretreated animals.
摘要
- 评估了二羟基苯丙氨酸（DOPA）和二羟基苯丝氨酸（DOPS）对雄性Wistar大鼠睡眠-觉醒周期的作用。2. 在比较研究中，在注射DOPA或DOPS之前，用丝氨酸三羟基苄基肼（RO 4-4602）抑制脑外脱羧酶。3. 给予DOPA（80-160mg/kg，腹腔注射），无论之前是否抑制外周脱羧酶，都会使慢波活动最初显著增加，这可能与5-羟色胺的释放有关。4. 在随后的8小时时间段内，DOPA显著减少慢波睡眠和快速眼动睡眠（REM），并增加觉醒。5. DOPS（80-160mg/kg，腹腔注射）除了在RO 4-4602预处理的动物中给予160mg/kg后首次REM发作的潜伏期缩短外，对睡眠-觉醒周期没有显著影响。
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