Susić V, Masirević G
Gerontology. 1981;27(1-2):1-6. doi: 10.1159/000212442.
Investigations with dihydroergotoxine methane sulfonate (DHET, the active substance of Redergine) indicate that DHET acts on the sleep-wakefulness cycle of the cat by increasing wakefulness and slow-wave sleep and decreasing rapid eye movement sleep. DHET was administered intraperitoneally at a dose of 1.0 mg/kg for 5 successive days. The effects were fairly stable, although with a tendency to diminish with time. Such alterations in the sleep-wakefulness cycle are discussed as possible indices of the beneficial effects seen in elderly patients treated with DHET.
对甲磺酸二氢麦角毒碱（DHET，氢化麦角碱的活性物质）的研究表明，DHET通过增加觉醒和慢波睡眠以及减少快速眼动睡眠来作用于猫的睡眠-觉醒周期。以1.0毫克/千克的剂量连续5天腹腔注射DHET。尽管有随时间减弱的趋势，但其效果相当稳定。睡眠-觉醒周期的这种变化被认为是在用DHET治疗的老年患者中所见有益效果的可能指标。
