Covelli V, Massari F, Fallacara C, Munno I, Pellegrino N M, Jirillo E, Savastano S, Ghiggi M R, Tommaselli A P, Lombardi G
Chair of Neurology, 2nd Medical School, University of Naples, Italy.
Int J Neurosci. 1991 Nov;61(1-2):53-60. doi: 10.3109/00207459108986270.
Tumor Necrosis Factor-alpha/cachectin (TNF-alpha/cachectin), Lipopolysaccharide (LPS), ACTH, beta-Endorphin (beta-EPH), and Cortisol (F) levels were determined in 33 Headache patients: 22 patients were affected with Migraine (M) and 11 patients with Chronic Type Tension Headache (CTTH). TNF-alpha/cachectin serum level was detected in 15 out of 22 migraneous patients and in no CTTH patients. Plasma LPS was observed in 11 out of 15 TNF-alpha/cachectin positive migraneous patients (73%) and in 3 out of 11 CTTH patients (27%). A negative correlation was observed between TNF-alpha/cachectin values and either ACTH or beta-EPH. In the group of migraneous patients the presence of serum TNF-alpha/cachectin showed a sensibility of .6 and a specificity of 1. The endocrine and immunological implications concerning these data are discussed.
测定了33例头痛患者的肿瘤坏死因子-α/恶病质素（TNF-α/恶病质素）、脂多糖（LPS）、促肾上腺皮质激素（ACTH）、β-内啡肽（β-EPH）和皮质醇（F）水平：22例为偏头痛（M）患者，11例为慢性紧张型头痛（CTTH）患者。22例偏头痛患者中有15例检测到TNF-α/恶病质素血清水平，而CTTH患者中未检测到。15例TNF-α/恶病质素阳性的偏头痛患者中有11例（73%）观察到血浆LPS，11例CTTH患者中有3例（27%）观察到。观察到TNF-α/恶病质素值与ACTH或β-EPH之间呈负相关。在偏头痛患者组中，血清TNF-α/恶病质素的存在显示出敏感性为0.6，特异性为1。讨论了这些数据的内分泌和免疫学意义。
