Headache Department, Iranian Center of Neurological Research¸ Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neurol Sci. 2018 Oct;39(10):1741-1749. doi: 10.1007/s10072-018-3493-0. Epub 2018 Jul 15.
The exact mechanism of the migraine pathophysiology remained unclear. Although there are some reports showing low-grade inflammation in migraineurs, further studies are needed in this field. Thus, we designed a study to evaluate the serum levels of two main proinflammatory markers in migraine patients. In this case-control research, 43 migraine patients (23 chronic and 20 episodic migraineurs) and 40 age-sex-matched headache-free controls were studied. Demographic, dietary, and anthropometric data, headache characteristics, and serum C-reactive proteins (CRP) and tumor necrosis factor-alpha (TNF-α) assessments were collected. The mean ± SD age of the case and control groups were 36.98 ± 9.91 and 34.84 ± 9.75 years respectively. Compared to control subjects, both episodic and chronic migraineurs had significantly higher median levels of TNF-α (0.24, 0.95, and 1.90 pg/ml, respectively; P value < 0.001). Also, we observed a positive association between the TNF-α levels and the odds of having migraine after considering gender, age, body mass index, and dietary intakes of energy, carbohydrate, protein, fat, and mono and poly unsaturated fatty acids in the multivariable regression models (OR = 2.15; 95% CI 1.31-3.52; P value < 0.001). However, no significant association was demonstrated between migraine and serum CRP (OR = 2.91; 95% CI 0.87-9.78; P value = 0.08). These findings supported that inflammatory state could be related to the pathogenesis of migraine and it can thus be suggested that this effect might be beyond migraine progression. Further detailed studies are needed to investigate the importance of these findings in the pathogenesis of migraine headache.
偏头痛病理生理学的确切机制仍不清楚。尽管有一些报告显示偏头痛患者存在低度炎症，但这一领域仍需要进一步研究。因此，我们设计了一项研究来评估偏头痛患者的两种主要促炎标志物的血清水平。在这项病例对照研究中，共纳入 43 名偏头痛患者（23 名慢性偏头痛患者和 20 名发作性偏头痛患者）和 40 名年龄、性别相匹配的无头痛对照者。收集了人口统计学、饮食和人体测量学数据、头痛特征以及血清 C 反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）评估。病例组和对照组的平均年龄分别为 36.98±9.91 岁和 34.84±9.75 岁。与对照组相比，发作性和慢性偏头痛患者的 TNF-α中位数水平显著更高（分别为 0.24、0.95 和 1.90 pg/ml；P 值均<0.001）。此外，在多变量回归模型中，考虑到性别、年龄、体重指数以及能量、碳水化合物、蛋白质、脂肪、单不饱和和多不饱和脂肪酸的饮食摄入量后，我们观察到 TNF-α水平与偏头痛发生的几率之间存在正相关关系（OR=2.15；95%CI 1.31-3.52；P 值<0.001）。然而，血清 CRP 与偏头痛之间没有显著相关性（OR=2.91；95%CI 0.87-9.78；P 值=0.08）。这些发现支持炎症状态可能与偏头痛的发病机制有关，因此可以认为这种作用可能超出偏头痛的进展。需要进一步的详细研究来探讨这些发现对偏头痛头痛发病机制的重要性。
