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Campylobacter, from obscurity to celebrity.弯曲杆菌，从默默无闻到备受瞩目。
Clin Microbiol Infect. 2004 Oct;10(10):868-76. doi: 10.1111/j.1469-0691.2004.00983.x.
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eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data.eBURST：从多位点序列分型数据推断相关细菌基因型簇之间的进化谱系模式。
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Fluoroquinolone susceptibility of Campylobacter strains, Senegal.塞内加尔弯曲杆菌菌株的氟喹诺酮敏感性
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DnaSP, DNA polymorphism analyses by the coalescent and other methods.DnaSP：通过合并及其他方法进行的DNA多态性分析
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Molecular evidence for dissemination of unique Campylobacter jejuni clones in Curaçao, Netherlands Antilles.在荷属安的列斯群岛库拉索岛空肠弯曲菌独特克隆传播的分子证据。
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Genetic diversity of Campylobacter jejuni isolates from farm animals and the farm environment.来自农场动物和农场环境的空肠弯曲菌分离株的遗传多样性。
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Multilocus sequence typing for comparison of veterinary and human isolates of Campylobacter jejuni.多位点序列分型用于比较空肠弯曲菌的兽医分离株和人类分离株。
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Phenotypic and genotypic relationship between Campylobacter spp isolated from humans and chickens in Northern Ireland--a comparison of three phenotyping and two genotyping schemes.北爱尔兰从人类和鸡中分离出的弯曲杆菌属的表型和基因型关系——三种表型分型和两种基因分型方案的比较
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Cattle and sheep farms as reservoirs of Campylobacter.作为弯曲杆菌宿主的牛羊养殖场。
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10
Comparative genotyping of Campylobacter jejuni by amplified fragment length polymorphism, multilocus sequence typing, and short repeat sequencing: strain diversity, host range, and recombination.通过扩增片段长度多态性、多位点序列分型和短重复序列测序对空肠弯曲菌进行比较基因分型：菌株多样性、宿主范围和重组
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塞内加尔家禽空肠弯曲菌分离株的遗传多样性与喹诺酮耐药性

Genetic diversity and quinolone resistance in Campylobacter jejuni isolates from poultry in Senegal.

作者信息

Kinana Alfred Dieudonné, Cardinale Eric, Tall Fatou, Bahsoun Ibrahim, Sire Jean-Marie, Garin Benoit, Breurec Sebastien, Boye Cheikh Saad-Bouh, Perrier-Gros-Claude Jean-David

机构信息

Laboratoire de biologie médicale, Institut Pasteur de Dakar, 36 avenue Pasteur, Dakar, Sénégal.

出版信息

Appl Environ Microbiol. 2006 May;72(5):3309-13. doi: 10.1128/AEM.72.5.3309-3313.2006.

DOI:10.1128/AEM.72.5.3309-3313.2006
PMID:16672471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1472360/
Abstract

We used the multilocus sequence typing (MLST) method to evaluate the genetic diversity of 46 Campylobacter jejuni isolates from chickens and to determine the link between quinolone resistance and sequence type (ST). There were a total of 16 ST genotypes, and the majority of them belonged to seven clonal complexes previously identified by using isolates from human disease. The ST-353 complex was the most common complex, whereas the ST-21, ST-42, ST-52, and ST-257 complexes were less well represented. The resistance phenotype varied for each ST, and the Thr-86-Ile substitution in the GyrA protein was the predominant mechanism of resistance to quinolone. Nine of the 14 isolates having the Thr-86-Ile substitution belonged to the ST-353 complex. MLST showed that the emergence of quinolone resistance is not related to the diffusion of a unique clone and that there is no link between ST genotype and quinolone resistance. Based on silent mutations, different variants of the gyrA gene were shown to exist for the same ST. These data provide useful information for understanding the epidemiology of C. jejuni in Senegal.

摘要

我们采用多位点序列分型（MLST）方法评估了46株来自鸡的空肠弯曲菌分离株的遗传多样性，并确定喹诺酮耐药性与序列型（ST）之间的联系。共有16种ST基因型，其中大多数属于先前利用人类疾病分离株鉴定出的7个克隆复合体。ST-353复合体是最常见的复合体，而ST-21、ST-42、ST-52和ST-257复合体的代表性较差。每种ST的耐药表型各不相同，GyrA蛋白中的Thr-86-Ile替代是对喹诺酮耐药的主要机制。14株具有Thr-86-Ile替代的分离株中有9株属于ST-353复合体。MLST表明，喹诺酮耐药性的出现与单一克隆的传播无关，且ST基因型与喹诺酮耐药性之间没有联系。基于沉默突变，同一ST存在gyrA基因的不同变体。这些数据为了解塞内加尔空肠弯曲菌的流行病学提供了有用信息。