Kotoulas A O, Kotoulas O B, Kalamidas S
Department of Anatomy, Histology and Embryology, Medical School, University of Ioannina, Greece.
Histol Histopathol. 1991 Jul;6(3):421-6.
The effects of cyclic 3',5'-AMP, ergotamine or propranolol on newborn rat liver were studied by using biochemical assays, electron microscopy and quantitative morphometry. Cyclic AMP enhanced the normal postnatal rise in the glycogen-hydrolysing activity of acid alpha 1, 4 glucosidase but had no effect on the maltose-hydrolysing activity of the enzyme. The results suggest that these activities may be due to different enzymes. Propranolol prevented the postnatal increase in the glycogen-hydrolysing activity of acid glucosidase and the breakdown of lysosomal glycogen, indicating that these phenomena represent beta-adrenergic functions in newborn rats. Ergotamine also inhibited the postnatal increase in this activity and the lysosomal glycogen mobilization. A reasonable explanation for these results is that ergotamine interferes with the action or formation of cyclic AMP.
通过生化分析、电子显微镜检查和定量形态测定法，研究了环3',5'-腺苷酸、麦角胺或普萘洛尔对新生大鼠肝脏的影响。环磷酸腺苷增强了酸性α1,4葡萄糖苷酶糖原水解活性的正常出生后升高，但对该酶的麦芽糖水解活性没有影响。结果表明，这些活性可能归因于不同的酶。普萘洛尔阻止了酸性葡萄糖苷酶糖原水解活性的出生后增加以及溶酶体糖原的分解，表明这些现象代表新生大鼠中的β-肾上腺素能功能。麦角胺也抑制了该活性的出生后增加和溶酶体糖原动员。对这些结果的合理解释是麦角胺干扰了环磷酸腺苷的作用或形成。
