放线菌素D对新生大鼠肝细胞溶酶体的影响。
Effects of actinomycin D on the lysosomes of newborn rat hepatocytes.
作者信息
Kotoulas O B
机构信息
Department of Anatomy, Histology, and Embryology, Medical School, University of Ioannina, Greece.
出版信息
Anat Rec. 1988 Jan;220(1):103-7. doi: 10.1002/ar.1092200112.
The effects of actinomycin D on newborn rat liver were studied by using biochemical assays, electron microscopy, and quantitative morphometry. Actinomycin prevented the normal postnatal rise in acid a 1,4 glucosidase (maltase) activity and the breakdown of lysosomal glycogen. The results suggest that the postnasal increase in acid glucosidase activity is protein synthesis dependent. This enzyme is critical for the catabolism of the lysosomal glycogen in newborn rat hepatocytes.
通过生化分析、电子显微镜检查和定量形态测定法研究了放线菌素D对新生大鼠肝脏的影响。放线菌素可阻止出生后酸性α-1,4-葡萄糖苷酶（麦芽糖酶）活性的正常升高以及溶酶体糖原的分解。结果表明，出生后酸性葡萄糖苷酶活性的增加依赖于蛋白质合成。这种酶对于新生大鼠肝细胞中溶酶体糖原的分解代谢至关重要。
Zotero 插件