Kotoulas O B
Bull Assoc Anat (Nancy). 1984 Jun;68(201):189-97.
Certain effects of glucagon administration on newborn rat hepatocytes were studied using biochemical assays, electron microscopy and quantitative morphometry. Glucagon accelerated the normal postnatal hyaloplasmic glycogen breakdown and the lysosomal glycogen breakdown. The glucagon-treated animals showed an increased activity of the enzyme, acid a 1,4 glucosidase (maltase). The results suggest that the catabolism of lysosomal glycogen is controlled by those agents that regulate the catabolism of hyaloplasmic glycogen and that this control is mediated through changes in the activity of the lysosomal acid a 1,4 glucosidases.
利用生化分析、电子显微镜和定量形态学方法，研究了胰高血糖素给药对新生大鼠肝细胞的某些影响。胰高血糖素加速了出生后正常的透明质糖原分解和溶酶体糖原分解。经胰高血糖素处理的动物，其酸性α-1,4-葡萄糖苷酶（麦芽糖酶）的活性有所增加。结果表明，溶酶体糖原的分解代谢受调节透明质糖原分解代谢的因子控制，且这种控制是通过溶酶体酸性α-1,4-葡萄糖苷酶活性的变化介导的。
