Jensen Niels, Gartz Jochen, Laatsch Hartmut
Institute of Organic and Biomolecular Chemistry, Georg-August University Göttingen, Göttingen, Germany.
Planta Med. 2006 Jun;72(7):665-6. doi: 10.1055/s-2006-931576. Epub 2006 Apr 28.
The hallucinogenic mushroom Inocybe aeruginascens contains several typical Psilocybe alkaloids including psilocybin. We have now elucidated the structure of a further indole derivative named aeruginascin as the quaternary ammonium compound N, N, N-trimethyl-4-phosphoryloxytryptamine. Aeruginascin is closely related to the frog skin toxin bufotenidine (5-HTQ), a potent 5-HT3 receptor agonist, and has been found exclusively in Inocybe aeruginascens so far.
致幻蘑菇铜绿丝盖伞含有几种典型的裸盖菇生物碱，包括裸盖菇素。我们现已阐明了另一种吲哚衍生物铜绿菌素的结构，它是季铵化合物N，N，N-三甲基-4-磷酸氧基色胺。铜绿菌素与青蛙皮肤毒素蟾毒色胺（5-HTQ）密切相关，后者是一种有效的5-HT3受体激动剂，迄今为止仅在铜绿丝盖伞中发现。
