Usona Institute , 2780 Woods Hollow Road , Madison , Wisconsin 53711 , United States.
Department of Psychiatry , University of California San Diego , La Jolla , California 92093 , United States.
J Nat Prod. 2020 Feb 28;83(2):461-467. doi: 10.1021/acs.jnatprod.9b01061. Epub 2020 Feb 20.
A general synthetic method was developed to access known tryptamine natural products present in psilocybin-producing mushrooms. and experiments were then conducted to inform speculations on the psychoactive properties, or lack thereof, of the natural products. In animal models, psychedelic activity by baeocystin alone was not evident using the mouse head twitch response assay, despite its putative dephosphorylated metabolite, norpsilocin, possessing potent agonist activity at the 5-HT receptor.
开发了一种通用的合成方法，以获取存在于产生裸盖菇素的蘑菇中的已知色胺天然产物。然后进行了实验，以推测这些天然产物的致幻特性或缺乏致幻特性。在动物模型中，尽管其假定的去磷酸化代谢物 norpsilocin 在 5-HT 受体上具有很强的激动剂活性，但单独使用 baeocystin 进行的迷幻活性在小鼠头部抽搐反应测定中并不明显。
