Ramsaransing G S M, De Keyser J
Department of Neurology, University Medical Centre Groningen, Groningen, The Netherlands.
Acta Neurol Scand. 2006 Jun;113(6):359-69. doi: 10.1111/j.1600-0404.2006.00637.x.
Since the 1950s, it has been recognized that a subgroup of multiple sclerosis (MS) patients exists that shows little or no progression in the severity of the disease over time. This group is referred to as 'benign' MS. Although a substantial amount of research in MS indicates a multifactorial background in disease severity, to date it is still difficult to predict whether the course will be benign at onset and it is difficult to find factors that influence the course of the disease over time. Maintaining or restoring neural conduction inside a central nervous system lesion seems to be the essence of staying 'benign'.
自20世纪50年代以来，人们已经认识到存在一部分多发性硬化症（MS）患者，他们的疾病严重程度随时间推移几乎没有进展或进展甚微。这一群体被称为“良性”MS。尽管对MS的大量研究表明疾病严重程度存在多因素背景，但迄今为止，仍然很难在发病时预测病程是否会是良性的，也很难找到影响疾病随时间发展进程的因素。维持或恢复中枢神经系统病变内的神经传导似乎是保持“良性”的关键。
