Inoue Tomoko, Fukumoto Takaya, Ansai Shinichi, Kimura Tetsunori
Sapporo Institute for Dermatopathology, Sapporo, Japan.
J Dermatol. 2006 Apr;33(4):268-72. doi: 10.1111/j.1346-8138.2006.00065.x.
We report the first case of erythema induratum of Bazin (EIB) after Bacille Calmette-Guerin (BCG) vaccination in an infant. The patient developed recurrent multiple erythematous and subcutaneous nodules on his legs 2 months after a BCG vaccination. He had no other symptoms or family history of tuberculosis (TB). Histopathological findings revealed a granulomatous lobular panniculitis. EIB often appears as a chronic, nodular eruptions that frequently occur on the lower legs of females with tuberculin hypersensitivity. To date, only a few cases of infants with EIB have been reported. There have been no clinical reports of EIB after BCG vaccination. Our case suggests that Mycobacterium bovis in the BCG vaccination may have caused EIB.
我们报告了首例婴儿接种卡介苗（BCG）后发生的巴赞硬红斑（EIB）病例。该患者在接种BCG疫苗2个月后，腿部出现反复多发的红斑和皮下结节。他没有其他症状，也没有结核病（TB）家族史。组织病理学检查结果显示为肉芽肿性小叶性脂膜炎。EIB通常表现为慢性结节性皮疹，常见于有结核菌素超敏反应的女性小腿。迄今为止，仅有少数婴儿EIB病例报告。尚无BCG疫苗接种后发生EIB的临床报告。我们的病例提示，BCG疫苗中的牛分枝杆菌可能导致了EIB。
