Roy Pankaj G, Thompson Alastair M
Department of Surgery & Molecular Oncology, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK.
Breast. 2006 Dec;15(6):718-27. doi: 10.1016/j.breast.2006.02.005. Epub 2006 May 3.
Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues. It concludes by presenting the clinical, prognostic and therapeutic implications of our current knowledge of cyclin D1 in breast cancer.
细胞周期蛋白D1是乳腺癌中经常过度表达的蛋白质之一，也是常见的扩增基因之一。本文综述了细胞周期蛋白D1在细胞周期调控（正常和异常）、乳腺发育和致癌作用中的作用，以及其与乳腺组织中雌激素的关系。文章最后阐述了我们目前对细胞周期蛋白D1在乳腺癌方面的认识所具有的临床、预后和治疗意义。
