Hegel Mark T, Oxman Thomas E, Hull Jay G, Swain Karin, Swick Holly
Department of Psychiatry, Dartmouth Medical School, Hanover, NH 03755, USA.
Gen Hosp Psychiatry. 2006 May-Jun;28(3):205-12. doi: 10.1016/j.genhosppsych.2006.02.008.
The objectives of this study were to determine remission rates and predictors of improvement for minor depression following a 1-month watchful waiting period in primary care and to describe the watchful waiting processes.
Prior to randomization into a clinical trial for minor depression, 111 participants were entered into a 1-month watchful waiting period. Depression severity and predictors of improvement were measured at the start of watchful waiting. At the end of watchful waiting, remission rates were calculated and predictor variables were analyzed for their contribution toward predicting improvement.
Remission rates were low, ranging from 9% to 13%, depending on the measure. Avoidant coping style and frequency of engaging in active pleasant events at baseline accounted for the majority of change in depression. During watchful waiting, about one fifth of the sample (21%) had at least one contact with their physician and 27% reported using self-initiated treatments.
There is a low likelihood of spontaneous remission for treatment-seeking samples with minor depression in primary care. An avoidant coping style seriously interferes with remission, and engaging in regular active pleasant events confers an advantage. Feasible interventions for primary care that promote activity and decrease avoidant coping styles may improve outcomes. These findings may not generalize to community and non-treatment-seeking samples.
本研究的目的是确定在初级保健中经过1个月观察等待期后轻度抑郁症的缓解率及改善的预测因素,并描述观察等待过程。
在随机进入轻度抑郁症临床试验之前,111名参与者进入1个月的观察等待期。在观察等待开始时测量抑郁严重程度及改善的预测因素。在观察等待结束时,计算缓解率,并分析预测变量对预测改善的贡献。
缓解率较低,根据测量方法不同,在9%至13%之间。基线时的回避应对方式和参与积极愉快事件的频率占抑郁变化的大部分。在观察等待期间,约五分之一的样本(21%)至少与他们的医生有过一次接触,27%报告使用了自我启动的治疗方法。
在初级保健中寻求治疗的轻度抑郁症样本自发缓解的可能性较低。回避应对方式严重干扰缓解,而定期参与积极愉快的事件具有优势。在初级保健中促进活动并减少回避应对方式的可行干预措施可能会改善结果。这些发现可能不适用于社区和未寻求治疗的样本。